Top Active Series A Investors & VCs Funding Startups in the US in 2025

Last update to database: October 05, 2026

Leading Growth-Stage Investors & Venture Capital Firms Funding Series A Startups Across the US

Series A funding continues to define a critical growth stage for US startups in 2025, helping founders scale proven products and expand into new markets. The top active Series A investors and VCs funding startups in the US are backing companies in AI, SaaS, fintech, health tech, and climate tech—sectors attracting the most venture capital activity this year.


These investors specialize in transforming early traction into sustainable growth, providing the capital, strategic guidance, and networks startups need to reach Series B and beyond. Many are headquartered in San Francisco, New York, Austin, and Boston, while others are global firms actively funding Series A rounds across the United States.


Our database highlights investors currently funding and supporting Series A startups in the US. Updated weekly, it offers founders, analysts, and business-development teams real-time visibility into who’s actively investing at the growth-stage level across America.

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Comprehensive Database of Active Series A Investors & VCs Funding US Startups – Updated Weekly

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Investor Name
Industry Focus Recent Investments Recent Investment Date Check Size Stage Focus Geography Focus Company Headquarters Firm Type Portfolio Size Portfolio Highlights Co-Investor Network
Wing Venture Capital Artificial Intelligence, Data & Analytics, Autonomous apps & Platforms, Web3, Biotechnology Subscribe to Unlock Subscribe to Unlock September, 2026 $1M-$10M Pre-Seed, Seed, Series A United States Palo Alto, California, United States Venture Capital 22 Subscribe to Unlock Subscribe to Unlock Y Combinator, Uncork Capital, Greylock, Tiger Global Management, Madrona Venture Group, Google Ventures
Spark Capital Enterprise Applications, Artificial Intelligence, Financial Services & FinTech, Web3 & Blockchain & Cryptocurrency, Marketplaces Subscribe to Unlock Subscribe to Unlock October, 2026 $1M-$10M Seed, Series A, Series B United States, San Francisco, Boston, New York City San Francisco, California, United States Venture Capital 326 Subscribe to Unlock Subscribe to Unlock SV Angel, Tiger Global Management, SoftBank Vision Fund, Andreessen Horowitz
RA Capital Health Care & Wellness, Biotechnology, Medical Devices, Pharmaceuticals, Life Sciences Subscribe to Unlock Subscribe to Unlock September, 2026 $1M-$10M Seed, Series A, Series B, Series C North America, Europe, Asia Boston, Massachusetts, United States Venture Capital 40 Subscribe to Unlock Subscribe to Unlock Flagship Pioneering, Spark Capital, Perceptive Advisors, Bain Capital Life Science
Chemistry SaaS & Software, Artificial Intelligence, Financial Services & FinTech, Information Technology Subscribe to Unlock Subscribe to Unlock September, 2026 $1M-$10M Pre-Seed, Seed, Series A, Series B United States San Francisco, California, United States Venture Capital 100 Subscribe to Unlock Subscribe to Unlock Unknown
3one4 Capital SaaS & Software, Consumer Internet, Financial Services & FinTech, Health Care & Wellness, Digital Media Subscribe to Unlock Subscribe to Unlock September, 2026 $500k-$1M Seed, Series A, Series B India Bengaluru, Karnataka, India Venture Capital 100 Subscribe to Unlock Subscribe to Unlock Alteria Capital, Accel, Alphatron Capital, BEENEXT Capital Management, Better Capital
Energy Impact Partners Energy, GreenTech & Sustainability, Science & Engineering, Manufacturing, Business & Professional Services Subscribe to Unlock Subscribe to Unlock September, 2026 $1M-$10M Seed, Series A, Series B, Series C, Series D North America, Europe New York, New York, United States Venture Capital 60 Subscribe to Unlock Subscribe to Unlock BP Ventures, Microsoft, Various strategic corporate partners
JLABS Biotechnology, Health Care & Wellness, Medical Devices, Pharmaceuticals Subscribe to Unlock Subscribe to Unlock September, 2026 $1M-$10M Series B, Series C, Series D North America, United States Raritan, New Jersey, United States Corporate VC 110 Subscribe to Unlock Subscribe to Unlock Alexandria Venture Investments, Novartis Venture Fund
A* Capital SaaS & Software, Artificial Intelligence, Financial Services & FinTech, Apps & Platforms, Internet Subscribe to Unlock Subscribe to Unlock September, 2026 $1M-$10M Pre-Seed, Seed, Series A United States, San Francisco San Francisco, California, United States Venture Capital 50 Subscribe to Unlock Subscribe to Unlock Founders Fund, Sequoia Capital, Andreessen Horowitz
Y Combinator Apps & Platforms, SaaS & Software, Artificial Intelligence, Biotechnology, EdTech and Training Subscribe to Unlock Subscribe to Unlock October, 2026 $500k-$1M Pre-Seed, Seed, Series A, Series B United States, North America United States Accelerator 5000 Subscribe to Unlock Subscribe to Unlock Top startup investors (network introduced by YC)
FUSE Artificial Intelligence, SaaS & Software, Health Care & Wellness, Logistics & Transportation, Financial Services & FinTech Subscribe to Unlock Subscribe to Unlock August, 2026 $1M-$10M Pre-Seed, Seed, Series A United States, Europe Seattle, Washington, United States Venture Capital 54 Subscribe to Unlock Subscribe to Unlock Icertis, Auth0, Apptio, Coinbase, Microsoft
E12 Ventures Artificial Intelligence, Data & Analytics, Robotics & Automation, Health Care & Wellness, AgriTech & Farming Subscribe to Unlock Subscribe to Unlock August, 2026 $500k-$1M Seed, Series A United States, Asia Palo Alto, California, United States Venture Capital 7 Subscribe to Unlock Subscribe to Unlock Unreasonable Impact, Khosla Ventures, Mitsui Global Investment, Origin Ventures Group, TELUS Global Ventures
Flare Capital Health Care & Wellness, SaaS & Software Subscribe to Unlock Subscribe to Unlock September, 2026 $1M-$10M Seed, Series A, Series B United States, Boston Boston, Massachusetts, United States Venture Capital 40 Subscribe to Unlock Subscribe to Unlock Unknown
Mantis Venture Capital Artificial Intelligence, SaaS & Software, Financial Services & FinTech, Gaming, Health Care & Wellness Subscribe to Unlock Subscribe to Unlock August, 2026 $100k-$250k Pre-Seed, Seed, Series A United States Los Angeles, California, United States Venture Capital 90 Subscribe to Unlock Subscribe to Unlock Sequoia Capital, Andreessen Horowitz, Lightspeed Venture Partners
Flying Fish Partners Artificial Intelligence, Machine Learning, SaaS & Software Subscribe to Unlock Subscribe to Unlock October, 2026 $100k-$250k Pre-Seed, Seed United States, Canada Seattle, Washington, United States Venture Capital 20 Subscribe to Unlock Subscribe to Unlock Unknown
Seven Stars Health Care & Wellness, Artificial Intelligence, SaaS & Software, Business & Professional Services Subscribe to Unlock Subscribe to Unlock August, 2026 $250k-$500k Seed, Series A United States San Francisco, California, United States Venture Capital 4 Subscribe to Unlock Subscribe to Unlock Lightspeed Venture Partners, Emergence, General Catalyst, Tornante Company, Union Square Ventures
8VC Artificial Intelligence, Financial Services & FinTech, Health Care & Wellness, Logistics & Transportation, SaaS & Software Subscribe to Unlock Subscribe to Unlock October, 2026 $500k–$1M Pre-seed, Seed, Series A, Series B, Growth, Late-stage United States, San Francisco, Austin Austin, Texas, United States Venture Capital 100 Subscribe to Unlock Subscribe to Unlock 9Yards Capital, Sequoia Capital, Andreessen Horowitz, Lightspeed, Founders Fund
Congruent Ventures Energy, GreenTech & Sustainability, Hardware, SaaS & Software, Data & Analytics Subscribe to Unlock Subscribe to Unlock August, 2026 $500k–$1M Pre-seed, Seed, Series A United States, Canada San Francisco, California, United States Venture Capital 58 Subscribe to Unlock Subscribe to Unlock Prelude Ventures, Climate Capital, DOE, National Science Foundation, Wellington
Crosslink Capital Business & Professional Services, SaaS & Software, Financial Services & FinTech, Information Technology, Data & Analytics Subscribe to Unlock Subscribe to Unlock September, 2026 $1M–$10M Seed, Series A North America, United States, San Francisco, Menlo Park San Francisco, California, United States Venture Capital 50 Subscribe to Unlock Subscribe to Unlock Unknown
Health Velocity Capital Health Care & Wellness, SaaS & Software Subscribe to Unlock Subscribe to Unlock August, 2026 $1M-$10M Series A, Series B, Series C United States San Francisco, California, United States Venture Capital 40 Subscribe to Unlock Subscribe to Unlock Unknown
Mischief SaaS & Software, Financial Services & FinTech, Health Care & Wellness, GreenTech & Sustainability, Blockchain & Cryptocurrency Subscribe to Unlock Subscribe to Unlock August, 2026 $1M-$10M Pre-Seed, Seed United States San Francisco, California, United States Venture Capital 50 Subscribe to Unlock Subscribe to Unlock Unknown
Acrew Capital Business & Professional Services, Financial Services & FinTech, Information Technology, SaaS & Software, Enterprise Applications Subscribe to Unlock Subscribe to Unlock August, 2026 $1M-$10M Seed, Series A, Series B United States, Mexico, Israel, Colombia, Indonesia Palo Alto, California, United States Venture Capital 140 Subscribe to Unlock Subscribe to Unlock Homebrew, Aspect Ventures, Y Combinator, Gaingels, Endeavor
Operator Partners Artificial Intelligence, Financial Services & FinTech, Health Care & Wellness, SaaS & Software, Cyber Security & Privacy Subscribe to Unlock Subscribe to Unlock August, 2026 $500k–$1M Pre-Seed, Seed, Series A, Series B United States, Colombia New York City, New York, United States Venture Capital 150 Subscribe to Unlock Subscribe to Unlock NFX, Maverick Capital, Brainchild, LaunchPad, Comcast Ventures
Lightbank SaaS & Software, Artificial Intelligence, Financial Services & FinTech, Health Care & Wellness, E-Commerce & Retail Subscribe to Unlock Subscribe to Unlock September, 2026 $1M-$10M Pre-Seed, Seed, Series A United States, Chicago, Midwest Chicago, Illinois, United States Venture Capital 150 Subscribe to Unlock Subscribe to Unlock Andreessen Horowitz, Sequoia Capital, Accel, Lightspeed Venture Partners, Battery Ventures
Andreessen Horowitz Artificial Intelligence, Biotechnology, Blockchain & Cryptocurrency, Financial Services & FinTech, Gaming Subscribe to Unlock Subscribe to Unlock October, 2026 $500k–$1M Pre-seed, Seed, Series A, Series B, Growth, Late-stage North America, United States Menlo Park, California, United States Venture Capital 1000 Subscribe to Unlock Subscribe to Unlock Thrive Capital, General Catalyst, Alumni Ventures, Sequoia Capital, Accel
SV Health Investors Biotechnology, Health Care & Wellness, Medical Devices, Healthcare services Subscribe to Unlock Subscribe to Unlock August, 2026 $10M–$20M Series A, Series B, Series C, Series D United States, United Kingdom Boston, Massachusetts, United States Venture Capital 75 Subscribe to Unlock Subscribe to Unlock Unknown
S3 Ventures Business & Professional Services, Information Technology, Health Care & Wellness, Apps & Platforms, SaaS & Software Subscribe to Unlock Subscribe to Unlock October, 2026 $500k-$1M Seed, Series A, Series B United States, Texas, Austin Austin, Texas, United States Venture Capital 60 Subscribe to Unlock Subscribe to Unlock Unknown
Bloomberg Beta Enterprise Applications, Artificial Intelligence, High Tech, Enterprise Infrastructure, SaaS & Software Subscribe to Unlock Subscribe to Unlock August, 2026 $500K-$1M Seed, Series A United States, San Francisco San Francisco, New York City, United States Venture Capital 149 Subscribe to Unlock Subscribe to Unlock Precursor Ventures, Insight Partners, Andreessen Horowitz, Coatue
OrbiMed Biotechnology, Health Care & Wellness, Pharmaceuticals, Medical Devices, Digital Health Subscribe to Unlock Subscribe to Unlock September, 2026 $1M–$10M Pre-seed, Seed, Series A, Series B, Growth, Late-stage North America, Asia, Europe, Middle East New York, New York, United States Venture Capital 500 Subscribe to Unlock Subscribe to Unlock Unknown
UpHonest Capital ConsumerTech, Enterprise, Deeptech, AgriTech, Artificial Intelligence Subscribe to Unlock Subscribe to Unlock September, 2026 $50k-$100k Angel, Pre-Seed, Seed, Series A United States, Silicon Valley, New York, Seattle Palo Alto, California, United States Venture Capital 500 Subscribe to Unlock Subscribe to Unlock Sequoia, Andreessen Horowitz, Accel, Lightspeed, Founders Fund
CEAS Investments SaaS & Software, Data & Analytics, Artificial Intelligence, Logistics & Transportation, Government & Military Tech Subscribe to Unlock Subscribe to Unlock September, 2026 $250k-$500k Pre-Seed, Seed, Series A, Series B, Series C, Series D United States, Canada Delray Beach, Florida, United States Family Office 40 Subscribe to Unlock Subscribe to Unlock Unknown
Base10 Partners Financial Services & FinTech, SaaS & Software, Enterprise Applications, Artificial Intelligence, Business & Professional Services Subscribe to Unlock Subscribe to Unlock October, 2026 $1M–$10M Seed, Series A United States, San Francisco San Francisco, California, United States Venture Capital 128 Subscribe to Unlock Subscribe to Unlock Tiger Global Management, Y Combinator, Andreessen Horowitz, SVB, Headline
Also Capital Robotics & Automation (categorize under Robotics as not listed, choose closest: Science & Engineering), Artificial Intelligence, Health Care & Wellness, Manufacturing, Energy Subscribe to Unlock Subscribe to Unlock August, 2026 $250k-$500k Pre-Seed, Seed, Series A, Series C Unknown New York, New York, United States Venture Capital 14 Subscribe to Unlock Subscribe to Unlock Unknown
Serena Ventures Financial Services & FinTech, Health Care & Wellness, Consumer, Blockchain & Cryptocurrency Subscribe to Unlock Subscribe to Unlock August, 2026 $100k-$500k Pre-Seed, Seed, Series A United States, San Francisco New York, New York, United States Venture Capital 80 Subscribe to Unlock Subscribe to Unlock Unknown
M13 Apps & Platforms, SaaS & Software, Artificial Intelligence, E-Commerce & Retail, Health Care & Wellness Subscribe to Unlock Subscribe to Unlock September, 2026 $500k–$1M Seed, Series A United States Santa Monica, California, United States Venture Capital 200 Subscribe to Unlock Subscribe to Unlock Bessemer Venture Partners, Fuel Capital, Compound, Homebrew, Union Square Ventures
Mana Ventures Software & SaaS, Artificial Intelligence, Deep Tech Subscribe to Unlock Subscribe to Unlock August, 2026 $100k-$250k Angel, Pre-Seed, Seed, Series A United States, Asia San Francisco, California, United States Venture Capital 300 Subscribe to Unlock Subscribe to Unlock Dropbox, Google, HotelTonight, Wordpress, Oculus
Venrock Technology, Health Care & Wellness, Cyber Security & Privacy, SaaS & Software, Artificial Intelligence Subscribe to Unlock Subscribe to Unlock August, 2026 $1M-$10M Seed, Series A, Series B, Series C United States Palo Alto, California, United States Venture Capital 125 Subscribe to Unlock Subscribe to Unlock Cormorant Asset Management, Logos Capital, T. Rowe Price Group, The Invus Group, Meritech Capital Partners
NVIDIA Artificial Intelligence, Hardware, Data & Analytics, SaaS & Software, Science & Engineering Subscribe to Unlock Subscribe to Unlock September, 2026 $1M-$10M Seed, Series A, Series B United States, North America, Europe, Asia Santa Clara, California, United States Corporate VC 120 Subscribe to Unlock Subscribe to Unlock Sequoia Capital, Andreessen Horowitz, Lightspeed Venture Partners, Accel Partners, Kleiner Perkins
A.Capital Ventures Artificial Intelligence, Consumer & Enterprise Technology, Crypto, SaaS & Software Subscribe to Unlock Subscribe to Unlock August, 2026 $500k-$1M Seed, Series A United States Menlo Park, California, United States Venture Capital 124 Subscribe to Unlock Subscribe to Unlock Andreessen Horowitz, Lerer Hippeau, Fuel Capital, Y Combinator, Thirty Five Ventures
Bessemer Artificial Intelligence, Biotechnology, Cyber Security & Privacy, Financial Services & FinTech, SaaS & Software Subscribe to Unlock Subscribe to Unlock October, 2026 $1M–$10M Seed, Series A, Series B, Series C North America, Europe, Israel, India San Francisco, California, United States Venture Capital 390 Subscribe to Unlock Subscribe to Unlock Unknown
Stage 2 Capital SaaS & Software, Financial Services & FinTech, Enterprise Applications, Artificial Intelligence, Data & Analytics Subscribe to Unlock Subscribe to Unlock September, 2026 $500k-$1M Series A, Seed United States, United Kingdom, Australia United States Venture Capital 55 Subscribe to Unlock Subscribe to Unlock Heartland Ventures, M25, Flybridge Capital Partners
Maverick Ventures Cyber Security & Privacy, Health Care & Wellness, E-Commerce & Retail, Artificial Intelligence, Marketing, Advertising & Sales Subscribe to Unlock Subscribe to Unlock August, 2026 $1M-$10M Pre-Seed, Seed, Series A, Series B, Series C, Series D United States, South Korea San Francisco, California, United States Venture Capital 40 Subscribe to Unlock Subscribe to Unlock health systems, insurers, endowments, industrial conglomerates
SpringTide Ventures Health Care & Wellness, Information Technology, SaaS & Software, Artificial Intelligence Subscribe to Unlock Subscribe to Unlock October, 2026 $500k-$1M Seed, Series A United States Cambridge, Massachusetts, United States Venture Capital 10 Subscribe to Unlock Subscribe to Unlock Unknown
Playground Global Artificial Intelligence, Engineered Biology, Next-Gen Compute, Energy Transition, Automation Subscribe to Unlock Subscribe to Unlock September, 2026 $1M-$10M Pre-Seed, Seed, Series A United States Palo Alto, California, United States Venture Capital 40 Subscribe to Unlock Subscribe to Unlock Unknown
Greycroft SaaS & Software, Artificial Intelligence, Sustainability, Consumer Brands, Financial Services & FinTech Subscribe to Unlock Subscribe to Unlock October, 2026 $1M-$10M Seed, Series A, Series B, Series C United States New York, New York, United States Venture Capital 400 Subscribe to Unlock Subscribe to Unlock Sequoia Capital, Andreessen Horowitz, Accel, Lightspeed Venture Partners, General Catalyst
Sequoia Capital Energy, Financial Services & FinTech, Health Care & Wellness, Information Technology, SaaS & Software Subscribe to Unlock Subscribe to Unlock October, 2026 $1M-$10M Seed, Series A, Series B, Growth United States, China, India Menlo Park, California, United States Venture Capital 1605 Subscribe to Unlock Subscribe to Unlock Lightspeed Venture Partners, In-Q-Tel, 8VC, Pantera Capital, Kleiner Perkins
Lifespan Vision Ventures Biotechnology, Health Care & Wellness, Science & Engineering, Artificial Intelligence, SaaS & Software Subscribe to Unlock Subscribe to Unlock August, 2026 $500k-$1M Seed, Series A United States Norwalk, Connecticut, United States Venture Capital 20 Subscribe to Unlock Subscribe to Unlock Unknown
HearstLab Enterprise Technology, Data & Analytics, Financial Services & FinTech, Health Care & Wellness, Media & Content Creation, Logistics & Transportation Subscribe to Unlock Subscribe to Unlock August, 2026 $500k-$1M Seed, Series A United States, Netherlands, Spain, United Kingdom, Saudi Arabia, Japan New York, New York, United States Corporate VC 80 Subscribe to Unlock Subscribe to Unlock Unknown
Swift Ventures E-Commerce & Retail, Consumer Internet, Enterprise Applications, Artificial Intelligence, Automation Subscribe to Unlock Subscribe to Unlock August, 2026 $500k-$1M Pre-Seed, Seed United States San Francisco, California, United States Venture Capital 30 Subscribe to Unlock Subscribe to Unlock Bloomberg BETA, CRV, Human Ventures, Lightspeed Venture Partners, True Ventures
GoPoint Ventures Artificial Intelligence, SaaS & Software, Energy, Logistics & Transportation, Manufacturing Subscribe to Unlock Subscribe to Unlock August, 2026 $500k-$1M Seed, Series A United States Montclair, New Jersey, United States Venture Capital 25 Subscribe to Unlock Subscribe to Unlock Unknown
The O.H.I.O. Fund Advanced Manufacturing, Biotechnology, Real Estate, Infrastructure, Financial Services & FinTech Subscribe to Unlock Subscribe to Unlock August, 2026 $500k-$1M Seed, Series A United States, Ohio Cleveland, Ohio, United States Venture Capital 45 Subscribe to Unlock Subscribe to Unlock Institutions, Corporations, Family Offices, High-Net-Worth Individuals, Venture Capital Funds

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