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Updated List of Top Active Investors & VCs Based in the US in 2025
Last update to database: April 06, 2026
Leading Investors & Venture Capital Firms Headquartered in the United States
In 2025, the US continues to serve as the central hub for global venture capital and private investment activity. The top active investors and VCs based in the United States are leading the charge in funding innovation across every major sector—from AI and fintech to health tech, SaaS, and clean energy.
These US-headquartered firms operate from major centers like San Francisco, New York, and Boston, but their investment reach extends worldwide. They’re not just providing capital—they’re backing visionary founders and shaping the next generation of high-growth companies.
Our database highlights investors and venture capital firms headquartered in the US who are currently active in startup funding. Updated weekly, it’s the most comprehensive source for discovering the firms driving venture activity across the United States.
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Updated List of Top Active Investors & VCs Based in the US in 2025
Last update to database: April 06, 2026
Subscribe to Unlock Active Startup Investors
Request AccessConnect with active investors funding startups in your region or industry. Subscribe to unlock full firm and contact data.
Leading Investors & Venture Capital Firms Headquartered in the United States
In 2025, the US continues to serve as the central hub for global venture capital and private investment activity. The top active investors and VCs based in the United States are leading the charge in funding innovation across every major sector—from AI and fintech to health tech, SaaS, and clean energy.
These US-headquartered firms operate from major centers like San Francisco, New York, and Boston, but their investment reach extends worldwide. They’re not just providing capital—they’re backing visionary founders and shaping the next generation of high-growth companies.
Our database highlights investors and venture capital firms headquartered in the US who are currently active in startup funding. Updated weekly, it’s the most comprehensive source for discovering the firms driving venture activity across the United States.
Comprehensive Database of Active Investors & VCs Based in the US – Updated Weekly
This data is delayed by 4 weeks. Subscribe for instant access to real-time funding rounds and contact data.
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Investor Name
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Industry Focus | Recent Investments | Recent Investment Date | Check Size | Stage Focus | Geography Focus | Company Headquarters | Firm Type | Portfolio Size | Portfolio Highlights | Co-Investor Network |
|---|---|---|---|---|---|---|---|---|---|---|---|
| Atomic | Consumer, Health Care & Wellness, SaaS & Software, Financial Services & FinTech, Information Technology | Subscribe to Unlock Subscribe to Unlock | March, 2026 | $1M-$10M | Seed | United States | Miami, Florida, United States | Venture Capital | 50 | Subscribe to Unlock Subscribe to Unlock | Andreessen Horowitz, Sequoia Capital, Lightspeed Venture Partners |
| OrbiMed | Biotechnology, Health Care & Wellness, Pharmaceuticals, Medical Devices, Digital Health | Subscribe to Unlock Subscribe to Unlock | April, 2026 | $1M–$10M | Pre-seed, Seed, Series A, Series B, Growth, Late-stage | North America, Asia, Europe, Middle East | New York, New York, United States | Venture Capital | 500 | Subscribe to Unlock Subscribe to Unlock | Unknown |
| Third Prime | Financial Services & FinTech, Blockchain & Cryptocurrency, PropTech, SaaS & Software, Artificial Intelligence | Subscribe to Unlock Subscribe to Unlock | March, 2026 | $1M-$10M | Seed, Series A, Series B | United States | New York, New York, United States | Venture Capital | 83 | Subscribe to Unlock Subscribe to Unlock | Gaingels, Valar Ventures, Coinbase Ventures, Tiger Global Management, Digital Currency Group |
| Anthemis Group | Financial Services & FinTech, Enterprise Applications, High Tech, SaaS & Software, Artificial Intelligence | Subscribe to Unlock Subscribe to Unlock | March, 2026 | $1M-$10M | Seed, Series A, Series B, Late Stage Venture | United States, United Kingdom, Europe | New York, New York, United States | Venture Capital | 186 | Subscribe to Unlock Subscribe to Unlock | Techstars, Y Combinator, Plug and Play Tech Center, EIC Fund, SBI Investment |
| Clocktower Ventures | Financial Services & FinTech, GreenTech & Sustainability | Subscribe to Unlock Subscribe to Unlock | March, 2026 | $100k-$250k | Pre-Seed, Seed, Series A | North America, Europe, Asia | Santa Monica, California, United States | Venture Capital | 40 | Subscribe to Unlock Subscribe to Unlock | Unknown |
| Shine Capital | Business & Professional Services, Hardware, Financial Services & FinTech, Media & Content Creation, Environmental Services (B2B) | Subscribe to Unlock Subscribe to Unlock | March, 2026 | $250k-$500k | Pre-Seed, Seed, Series A | United States, Israel | New York, New York, United States | Venture Capital | 69 | Subscribe to Unlock Subscribe to Unlock | BoxGroup, Andreessen Horowitz, Lux Capital, Quiet Capital, Union Square Ventures |
| TheVentureCity | Artificial Intelligence, Financial Services & FinTech, Health Care & Wellness, Logistics & Transportation, Cyber Security & Privacy | Subscribe to Unlock Subscribe to Unlock | March, 2026 | $1M-$10M | Series A | United States, Europe, South America | Miami, Florida, United States | Venture Capital | 120 | Subscribe to Unlock Subscribe to Unlock | Unknown |
| Founder Collective | Apps & Platforms, Information Technology, SaaS & Software, Artificial Intelligence, Financial Services & FinTech | Subscribe to Unlock Subscribe to Unlock | March, 2026 | $500k–$1M | Pre-Seed, Seed | United States, specifically Cambridge, MA and New York, NY | Cambridge, Massachusetts, United States | Venture Capital | 100 | Subscribe to Unlock Subscribe to Unlock | Unknown |
| Precursor Ventures | SaaS & Software, Hardware, Business & Professional Services, Consumer, Enterprise | Subscribe to Unlock Subscribe to Unlock | March, 2026 | $100k-$250k | Pre-Seed, Seed | North America, United States | San Francisco, California, United States | Venture Capital | 400 | Subscribe to Unlock Subscribe to Unlock | Unknown |
| Dollar Donation Club | Social & Lifestyle Networks, Financial Services & FinTech, SaaS & Software, Data & Analytics | Subscribe to Unlock Subscribe to Unlock | March, 2026 | $50k-$100k | Pre-Seed, Seed, Series A | North America, United States, Austin, Texas | Austin, Texas, United States | Venture Capital | 10 | Subscribe to Unlock Subscribe to Unlock | DuContra Ventures, Entrepreneur Ventures, Cognic Capital |
| Flintlock Capital | Financial Services & FinTech, Technology | Subscribe to Unlock Subscribe to Unlock | March, 2026 | $1M-$10M | Pre-Seed, Seed, Series A | United States | Tysons Corner, Virginia, United States | Venture Capital | 25 | Subscribe to Unlock Subscribe to Unlock | Unknown |
| U.S. Venture Partners | SaaS & Software, Cyber Security & Privacy, E-Commerce & Retail, Health Care & Wellness, Artificial Intelligence | Subscribe to Unlock Subscribe to Unlock | March, 2026 | $1M-$10M | Seed, Series A, Series B | United States, Israel | Menlo Park, California, United States | Venture Capital | 500 | Subscribe to Unlock Subscribe to Unlock | Unknown |
| Massachusetts Clean Energy Center | Energy, GreenTech & Sustainability, Manufacturing, Science & Engineering, Hardware | Subscribe to Unlock Subscribe to Unlock | March, 2026 | $100k-$250k | Pre-Seed, Seed, Series A, Series B | United States, Massachusetts | Boston, Massachusetts, United States | Other | 30 | Subscribe to Unlock Subscribe to Unlock | Climate Capital, National Science Foundation, MassVentures, MassChallenge |
| SG Credit Partners | Software & Platforms, Financial Services & FinTech, SaaS & Software | Subscribe to Unlock Subscribe to Unlock | March, 2026 | $50k-$100k | Seed, Series A | United States | Newport Beach, California, United States | Other | 10 | Subscribe to Unlock Subscribe to Unlock | Unknown |
| F-Prime | Health Care & Wellness, Biotechnology, SaaS & Software, Artificial Intelligence, Financial Services & FinTech | Subscribe to Unlock Subscribe to Unlock | March, 2026 | $1M-$10M | Seed, Series A, Series B, Series C, Series D | United States, Europe, Asia | Cambridge, Massachusetts, United States | Venture Capital | 499 | Subscribe to Unlock Subscribe to Unlock | Eight Roads, Fidelity Ventures, Various global VC partners |
| Whistler Capital Partners | Health Care & Wellness, Information Technology, SaaS & Software, Data & Analytics, Financial Services & FinTech | Subscribe to Unlock Subscribe to Unlock | March, 2026 | $10M-$20M | Series B, Series C, Series D | United States, Nashville | Nashville, Tennessee, United States | Private Equity | 40 | Subscribe to Unlock Subscribe to Unlock | Unknown |
| Susa Ventures | Artificial Intelligence, Financial Services & FinTech, Health Care & Wellness, SaaS & Software, Logistics & Transportation | Subscribe to Unlock Subscribe to Unlock | March, 2026 | $1M-$10M | Pre-Seed, Seed | United States | San Francisco, California, United States | Venture Capital | 100 | Subscribe to Unlock Subscribe to Unlock | Unknown |
| Arch Grants | SaaS & Software, Information Technology, Hardware, AgriTech & Farming, Consumer Products | Subscribe to Unlock Subscribe to Unlock | March, 2026 | $50k-$100k | Pre-Seed, Seed | United States, St. Louis | St. Louis, Missouri, United States | Accelerator | 291 | Subscribe to Unlock Subscribe to Unlock | Unknown |
| LRVHealth | Health Care & Wellness, SaaS & Software, Biotechnology, Business & Professional Services, Data & Analytics | Subscribe to Unlock Subscribe to Unlock | March, 2026 | $1M-$10M | Seed, Series A, Series B, Series C | United States, United Kingdom | Boston, Massachusetts, United States | Venture Capital | 62 | Subscribe to Unlock Subscribe to Unlock | HLM Venture Partners, 333 investors overall |
| Z Fellows | SaaS & Software, Artificial Intelligence, Information Technology, Web & Internet Platforms, Apps & Platforms | Subscribe to Unlock Subscribe to Unlock | March, 2026 | $10k-$100k | Pre-Seed, Seed | United States, San Francisco | San Francisco, California, United States | Accelerator | 40 | Subscribe to Unlock Subscribe to Unlock | Unknown |
| Konik Capital Partners | Financial Services & FinTech | Subscribe to Unlock Subscribe to Unlock | March, 2026 | $1M-$10M | Seed, Series A, Series B | North America | New York, New York, United States | Other | 10 | Subscribe to Unlock Subscribe to Unlock | Unknown |
| Ondas Networks | Artificial Intelligence, Hardware, Energy, Government & Military Tech, Electronics & Devices | Subscribe to Unlock Subscribe to Unlock | March, 2026 | $1M-$10M | Seed, Series A | United States, Israel | Boston, Massachusetts, United States | Other | 15 | Subscribe to Unlock Subscribe to Unlock | Unknown |
| 8VC | Artificial Intelligence, Financial Services & FinTech, Health Care & Wellness, Logistics & Transportation, SaaS & Software | Subscribe to Unlock Subscribe to Unlock | March, 2026 | $500k–$1M | Pre-seed, Seed, Series A, Series B, Growth, Late-stage | United States, San Francisco, Austin | Austin, Texas, United States | Venture Capital | 100 | Subscribe to Unlock Subscribe to Unlock | 9Yards Capital, Sequoia Capital, Andreessen Horowitz, Lightspeed, Founders Fund |
| Rev1 Ventures | SaaS & Software, Health Care & Wellness, Biotechnology, Advanced Materials, Financial Services & FinTech | Subscribe to Unlock Subscribe to Unlock | March, 2026 | $250k-$1M | Pre-Seed, Seed, Series A | United States, Midwest, Ohio | Columbus, Ohio, United States | Venture Capital | 140 | Subscribe to Unlock Subscribe to Unlock | Over 200 co-investment partners across Midwest and US |
| Google Ventures | Artificial Intelligence, Biotechnology, SaaS & Software, Health Care & Wellness, Information Technology | Subscribe to Unlock Subscribe to Unlock | March, 2026 | $1M–$10M | Seed, Series A, Series B, Growth | North America, Europe, Israel | Mountain View, California, United States | Venture Capital | 400 | Subscribe to Unlock Subscribe to Unlock | Unknown |
| 360 Capital | Climate Tech, Deep Tech, Digital-First Solutions | Subscribe to Unlock Subscribe to Unlock | March, 2026 | $500k-$1M | Pre-Seed, Seed, Series A, Series B | Europe, Italy, France, United Kingdom, Germany, Spain, Switzerland, Austria, Israel | Detroit, Michigan, United States | Venture Capital | 40 | Subscribe to Unlock Subscribe to Unlock | Various pan-European VCs across tech and climate sectors |
| Ribbit Capital | Information Technology, Financial Services & FinTech, Mobile Technology, Insurance Technology, Business & Professional Services | Subscribe to Unlock Subscribe to Unlock | April, 2026 | $1M-$10M | Seed, Series A, Series B, Series C | United States, Global | Palo Alto, California, United States | Venture Capital | 157 | Subscribe to Unlock Subscribe to Unlock | Andreessen Horowitz, Coatue Management, Coinbase Ventures, Index Ventures, Sequoia Capital |
| Knoll Ventures | Technology related (implied but not specifically listed) | Subscribe to Unlock Subscribe to Unlock | March, 2026 | $250k-$500k | Pre-Seed, Seed, Series A, Series B | United States, Atlanta, Austin, Chapel Hill | Atlanta, Georgia, United States | Venture Capital | 40 | Subscribe to Unlock Subscribe to Unlock | Unknown |
| Gates Foundation | Health Care & Wellness, Biotechnology, Education & Training, GreenTech & Sustainability, Social & Lifestyle Networks | Subscribe to Unlock Subscribe to Unlock | March, 2026 | $1M-$10M | Seed, Series A, Series B | United States, United Kingdom, Germany, Nigeria, Ethiopia, South Africa, India, China, Senegal | Seattle, Washington, United States | Other | 150 | Subscribe to Unlock Subscribe to Unlock | Unknown |
| Golden Section | SaaS & Software, Business & Professional Services, Information Technology, Data & Analytics, Financial Services & FinTech | Subscribe to Unlock Subscribe to Unlock | March, 2026 | $1M-$10M | Series B, Series C | United States, Houston | Houston, Texas, United States | Venture Capital | 30 | Subscribe to Unlock Subscribe to Unlock | Unknown |
| Sorenson Capital | Artificial Intelligence, Cyber Security & Privacy, SaaS & Software, Information Technology, DevTools & Computing Infrastructure | Subscribe to Unlock Subscribe to Unlock | March, 2026 | $1M-$10M | Seed, Series A, Series B, Series C | United States | Lehi, Utah, United States | Venture Capital | 147 | Subscribe to Unlock Subscribe to Unlock | Battery Ventures, Accel, Sequoia Capital, Andreessen Horowitz, Lightspeed Venture Partners |
| Teamworthy Ventures | Apps & Platforms, SaaS & Software, Financial Services & FinTech, EdTech and Training, Health Care & Wellness | Subscribe to Unlock Subscribe to Unlock | March, 2026 | $1M-$10M | Seed, Series A, Series B, Series C, Series D | United States, Canada, Spain | Greenwich, Connecticut, United States | Venture Capital | 50 | Subscribe to Unlock Subscribe to Unlock | Sageview Capital, Live Oak Ventures, Zigg Capital, Alumni Ventures, Index Ventures |
| 500 Global | SaaS & Software, Financial Services & FinTech, Artificial Intelligence, Health Care & Wellness, EdTech and Training | Subscribe to Unlock Subscribe to Unlock | April, 2026 | $100k-$250k | Pre-Seed, Seed, Series A | North America, Asia, Europe, Middle East | Palo Alto, California, United States | Venture Capital | 2600 | Subscribe to Unlock Subscribe to Unlock | Sequoia Capital, Y Combinator, Techstars, Accel Partners, Lightspeed Venture Partners |
| 100+ Accelerator | AgriTech & Farming, GreenTech & Sustainability, Food & Drink, Manufacturing, Health Care & Wellness | Subscribe to Unlock Subscribe to Unlock | March, 2026 | $50k-$100k | Pre-Seed, Seed | Global, including North America, Europe, Asia, South America, Africa (40 countries) | New York, New York, United States | Accelerator | 190 | Subscribe to Unlock Subscribe to Unlock | Anheuser-Busch InBev, The Coca-Cola Company, Colgate-Palmolive, Danone, Mondelēz International, Unilever |
| Washington Harbour | Technology, Media, Communications, Financial Services & FinTech, Business & Professional Services, Cyber Security & Privacy | Subscribe to Unlock Subscribe to Unlock | March, 2026 | $1M-$10M | Series B, Series C, Series D | United States | Arlington, Virginia, United States | Private Equity | 55 | Subscribe to Unlock Subscribe to Unlock | Unknown |
| HealthX Ventures | Health Care & Wellness, Data & Analytics, Artificial Intelligence, SaaS & Software, Business & Professional Services | Subscribe to Unlock Subscribe to Unlock | March, 2026 | $250k-$500k | Seed | United States | Madison, Wisconsin, United States | Venture Capital | 40 | Subscribe to Unlock Subscribe to Unlock | Sequoia Capital, Andreessen Horowitz, Redpoint Ventures |
| The Column Group | Biotechnology, Health Care & Wellness, Science & Engineering | Subscribe to Unlock Subscribe to Unlock | March, 2026 | $1M–$10M | Pre-Seed, Seed, Series A, Series B, Series C, Series D | United States, San Francisco | San Francisco, California, United States | Venture Capital | 55 | Subscribe to Unlock Subscribe to Unlock | Unknown |
| Mayfield | Artificial Intelligence, Financial Services & FinTech, Health Care & Wellness, SaaS & Software, Information Technology | Subscribe to Unlock Subscribe to Unlock | April, 2026 | $1M–$10M | Seed, Series A, Series B | United States, India | Menlo Park, California, United States | Venture Capital | 150 | Subscribe to Unlock Subscribe to Unlock | Unknown |
| Bluestein Ventures | Food & Drink, Health Care & Wellness, E-Commerce & Retail, Digital Technology, SaaS & Software | Subscribe to Unlock Subscribe to Unlock | March, 2026 | $500k-$1M | Pre-Seed, Seed, Series A | United States | Chicago, Illinois, United States | Venture Capital | 45 | Subscribe to Unlock Subscribe to Unlock | Unknown |
| Operator Partners | Artificial Intelligence, Financial Services & FinTech, Health Care & Wellness, SaaS & Software, Cyber Security & Privacy | Subscribe to Unlock Subscribe to Unlock | March, 2026 | $500k–$1M | Pre-Seed, Seed, Series A, Series B | United States, Colombia | New York City, New York, United States | Venture Capital | 150 | Subscribe to Unlock Subscribe to Unlock | NFX, Maverick Capital, Brainchild, LaunchPad, Comcast Ventures |
| Crescat Capital | Energy, Natural Resources, Financial Services & FinTech, Agriculture & Farming, Precious Metals | Subscribe to Unlock Subscribe to Unlock | March, 2026 | $20M+ | Other | Global, Emerging Markets | Denver, Colorado, United States | Other | 10 | Subscribe to Unlock Subscribe to Unlock | Unknown |
| Symbiotic Capital | Health Care & Wellness, Biotechnology | Subscribe to Unlock Subscribe to Unlock | March, 2026 | $20M+ | Seed, Series A, Series B | United States, Los Angeles | Los Angeles, California, United States | Other | 10 | Subscribe to Unlock Subscribe to Unlock | Unknown |
| Base10 Partners | Financial Services & FinTech, SaaS & Software, Enterprise Applications, Artificial Intelligence, Business & Professional Services | Subscribe to Unlock Subscribe to Unlock | April, 2026 | $1M–$10M | Seed, Series A | United States, San Francisco | San Francisco, California, United States | Venture Capital | 128 | Subscribe to Unlock Subscribe to Unlock | Tiger Global Management, Y Combinator, Andreessen Horowitz, SVB, Headline |
| Y Combinator | Apps & Platforms, SaaS & Software, Artificial Intelligence, Biotechnology, EdTech and Training | Subscribe to Unlock Subscribe to Unlock | April, 2026 | $500k-$1M | Pre-Seed, Seed, Series A, Series B | United States, North America | United States | Accelerator | 5000 | Subscribe to Unlock Subscribe to Unlock | Top startup investors (network introduced by YC) |
| Scout Ventures | Artificial Intelligence, Robotics, Cyber Security & Privacy, Quantum Computing, Aerospace & Defense | Subscribe to Unlock Subscribe to Unlock | March, 2026 | $500k-$1M | Seed, Series A | United States | Austin, Texas, United States | Venture Capital | 85 | Subscribe to Unlock Subscribe to Unlock | AVAIN Ventures, Decisive Point, Red Swan Ventures, Alumni Ventures, Vanedge Capital |
| Harbert Management Corporation | Financial Services & FinTech, Real Estate, Infrastructure, Health Care & Wellness | Subscribe to Unlock Subscribe to Unlock | March, 2026 | $10M-$20M | Series A, Series B, Series C, Series D | United States, Europe | Birmingham, Alabama, United States | Private Equity | 60 | Subscribe to Unlock Subscribe to Unlock | Unknown |
| BioGenerator | Biotechnology, Health Care & Wellness, AgriTech & Farming, Science & Engineering, SaaS & Software | Subscribe to Unlock Subscribe to Unlock | March, 2026 | $500k-$1M | Pre-Seed, Seed, Series A | United States, St Louis | St. Louis, Missouri, United States | Venture Capital | 80 | Subscribe to Unlock Subscribe to Unlock | Novo Holdings, New Enterprise Associates (NEA), Menlo Ventures, GV (Google Ventures), Leaps by Bayer |
| Relentless | Retail, Enterprise Applications, Consumer, Enterprise Infrastructure, Food & Drink | Subscribe to Unlock Subscribe to Unlock | March, 2026 | $100k-$250k | Seed | United States, India | Carlsbad, California, United States | Venture Capital | 4 | Subscribe to Unlock Subscribe to Unlock | Abhishek Goyal, Stride Ventures, Jungle Ventures, Vertex Ventures |
| Acrew Capital | Business & Professional Services, Financial Services & FinTech, Information Technology, SaaS & Software, Enterprise Applications | Subscribe to Unlock Subscribe to Unlock | March, 2026 | $1M-$10M | Seed, Series A, Series B | United States, Mexico, Israel, Colombia, Indonesia | Palo Alto, California, United States | Venture Capital | 140 | Subscribe to Unlock Subscribe to Unlock | Homebrew, Aspect Ventures, Y Combinator, Gaingels, Endeavor |
| H.C. Wainwright & Co. | Biotechnology, Pharmaceuticals, Health Care & Wellness, Financial Services & FinTech, Scientific Research | Subscribe to Unlock Subscribe to Unlock | April, 2026 | $1M-$10M | Series A, Series B, Series C | United States, North America | New York, New York, United States | Other | 10 | Subscribe to Unlock Subscribe to Unlock | Unknown |
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